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Comparative evaluation of quetiapine plus lamotrigine combination versus quetiapine monotherapy (and folic acid versus placebo) in bipolar depression (CEQUEL): a 2 × 2 factorial randomised trial.

Abstract:

Depressive symptoms are a major cause of disability in bipolar disorder and there are few safe and effective treatments. The combination of lamotrigine plus quetiapine potentially offers improved outcomes for people with bipolar depression. We aimed to determine if combination therapy with quetiapine plus lamotrigine leads to greater improvement in depressive symptoms over 12 weeks than quetiapine monotherapy plus lamotrigine placebo.In this double-blind, randomised, placebo-controlled, paral...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/s2215-0366(15)00450-2

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Psychiatry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Primary Care Health Sciences
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Psychiatry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Primary Care Health Sciences
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Psychiatry
Role:
Author
Publisher:
Elsevier
Journal:
Lancet Psychiatry More from this journal
Volume:
3
Issue:
1
Pages:
31-39
Publication date:
2015-12-11
DOI:
EISSN:
2215-0374
ISSN:
2215-0366
Language:
English
Keywords:
Pubs id:
pubs:584229
UUID:
uuid:0810007a-d0fa-4ab1-88b1-f44235c459e9
Local pid:
pubs:584229
Source identifiers:
584229
Deposit date:
2016-02-01

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