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Expression of paramyxovirus V proteins promotes replication and spread of hepatitis C virus in cultures of primary human fetal liver cells.

Abstract:

UNLABELLED: Here we demonstrate that primary cultures of human fetal liver cells (HFLC) reliably support infection with laboratory strains of hepatitis C virus (HCV), although levels of virus replication vary significantly between different donor cell preparations and frequently decline in a manner suggestive of active viral clearance. To investigate possible contributions of the interferon (IFN) system to control HCV infection in HFLC, we exploited the well-characterized ability of paramyxov...

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Publisher copy:
10.1002/hep.24557

Authors


Marukian, S More by this author
Catanese, MT More by this author
Sheahan, TP More by this author
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Journal:
Hepatology (Baltimore, Md.)
Volume:
54
Issue:
6
Pages:
1901-1912
Publication date:
2011-12-29
DOI:
EISSN:
1527-3350
ISSN:
0270-9139
URN:
uuid:080c8389-92cf-48c0-bfc4-51c8001dd473
Source identifiers:
426218
Local pid:
pubs:426218

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