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Phospholipase A2 is activated by tumor necrosis factor-alpha in primary hepatocytes stimulated by a deleted form of hepatocyte growth factor.

Abstract:

Several factors are released in the liver microenvironment immediately after injury. Among these factors TNF alpha is implicated as a regulator of hepatocyte proliferation. Hepatocytes in the intact liver are mostly in the G0 phase of the cell cycle and after injury (including collagenase perfusion) display a constitutive expression of the growth-regulated c-myc oncogene. TNF alpha co-added with dHGF in hepatocyte cultures, superinduced the DNA synthetic response observed at all time points. ...

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Publication status:
Published

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Publisher copy:
10.1006/bbrc.1995.2904

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Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
Journal:
Biochemical and biophysical research communications More from this journal
Volume:
217
Issue:
3
Pages:
1263-1270
Publication date:
1995-12-01
DOI:
EISSN:
1090-2104
ISSN:
0006-291X

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