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Synthesis, photolysis studies and in vitro photorelease of caged TRPV1 agonists and antagonists.

Abstract:
The synthesis of a range of caged TRPV1 agonists and antagonists is reported. The photolysis characteristics of these compounds, when irradiated with a 355 nm laser, have been studied and in all cases the desired compound was produced. Photolysis of a caged TRPV1 agonist in cultured trigeminal neurons produced responses that were consistent with the activation of TRPV1 receptors.
Publication status:
Published

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Publisher copy:
10.1039/b914981c

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Journal:
Organic and biomolecular chemistry More from this journal
Volume:
7
Issue:
22
Pages:
4695-4707
Publication date:
2009-11-01
DOI:
EISSN:
1477-0539
ISSN:
1477-0520
Language:
English
Keywords:
Pubs id:
pubs:41440
UUID:
uuid:0800043b-88b5-4bf6-9ab2-d8fd017bbcb4
Local pid:
pubs:41440
Source identifiers:
41440
Deposit date:
2012-12-19

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