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Journal article

The role of astrocytes in CNS tumors: pre-clinical models and novel imaging approaches.

Abstract:

Brain metastasis is a significant clinical problem, yet the mechanisms governing tumor cell extravasation across the blood-brain barrier (BBB) and CNS colonization are unclear. Astrocytes are increasingly implicated in the pathogenesis of brain metastasis but in vitro work suggests both tumoricidal and tumor-promoting roles for astrocyte-derived molecules. Also, the involvement of astrogliosis in primary brain tumor progression is under much investigation. However, translation of in vitro fin...

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Publication status:
Published

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Publisher copy:
10.3389/fncel.2013.00040

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Oncology
Role:
Author
Journal:
Frontiers in cellular neuroscience More from this journal
Volume:
7
Issue:
MAR
Pages:
40
Publication date:
2013-01-01
DOI:
EISSN:
1662-5102
ISSN:
1662-5102
Language:
English
Keywords:
Pubs id:
pubs:395963
UUID:
uuid:07ff5f37-05de-4122-97cb-e582eacad284
Local pid:
pubs:395963
Source identifiers:
395963
Deposit date:
2013-11-16

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