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Immunization with different formulations of Mycobacterium tuberculosis antigen 85A induces immune responses with different specificity and protective efficacy.

Abstract:

To test the relative efficacy of CD4 and CD8T cells in mediating protective immunity to Mycobacterium tuberculosis (Mtb), we compared three immunization regimes designed to induce preferentially each subset. BALB/c mice were immunized intranasally (i.n.) or parenterally with antigen 85A either in a recombinant Adenoviral vector (Ad85A), as recombinant protein (r85A) or as a set of overlapping 15mer peptides (p85A). For the first time we show that i.n. immunization with overlapping 85A synthet...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine
Role:
Author
Journal:
Vaccine
Volume:
31
Issue:
41
Pages:
4624-4631
Publication date:
2013-09-05
DOI:
EISSN:
1873-2518
ISSN:
0264-410X
URN:
uuid:07ff3018-7f59-48b7-8107-abdd28909d17
Source identifiers:
416296
Local pid:
pubs:416296

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