Treatment interruption in chronic HIV-1 infection: does it deliver?

Journal article

PURPOSE OF REVIEW: This review sets out to overview treatment interruption in chronic HIV-1 infection: what treatment interruption promised, results from recent trials, and what the future holds. RECENT FINDINGS: Recent studies have produced mixed results; several trials have been prematurely halted, whereas others have reported more positive outcomes. One consistent finding has been the identification of the CD4 T-cell count nadir as a critical parameter in determining the outcome of treatment interruption. SUMMARY: The use of treatment interruption is still controversial, but it is becoming clear that certain individuals could benefit, and partial treatment interruption strategies warrant further investigation.

Authors: Willberg, C; Nixon, D

• Journal: Current opinion in HIV and AIDS
• Volume: 2
• Issue: 1
• Pages: 26-30
• Publication date: 2007-01-01
• DOI: 10.1097/coh.0b013e3280119307
• EISSN: 1746-6318
• ISSN: 1746-630X
• Language: English
• Keywords: HIV-1; Chronic infection; Treatment interruption; Highly active antiretroviral therapy