Interaction of insulin and PPAR-α genes in Alzheimer's disease: the Epistasis Project.

Journal article

Altered glucose metabolism has been described in Alzheimer's disease (AD). We re-investigated the interaction of the insulin (INS) and the peroxisome proliferator-activated receptor alpha (PPARA) genes in AD risk in the Epistasis Project, including 1,757 AD cases and 6,294 controls. Allele frequencies of both SNPs (PPARA L162V, INS intron 0 A/T) differed between Northern Europeans and Northern Spanish. The PPARA 162LL genotype increased AD risk in Northern Europeans (p = 0.04), but not in Nor...

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Authors: Kölsch, H; Lehmann, D; Ibrahim-Verbaas, C; Combarros, O; van Duijn, C

• Publication status: Published
• Journal: Journal of neural transmission (Vienna, Austria : 1996)
• Volume: 119
• Issue: 4
• Pages: 473-479
• Publication date: 2012-04-01
• DOI: 10.1007/s00702-011-0732-4
• EISSN: 1435-1463
• ISSN: 0300-9564
• Language: English
• Keywords: PPAR alpha; Gene Frequency; Epistasis, Genetic; Aged; Genetic Predisposition to Disease; Apolipoprotein E4; Alzheimer Disease; Polymorphism, Single Nucleotide; Aged, 80 and over; Genetic Association Studies; Female; Male; Insulin; Humans; Genotype; Europe