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Interaction of insulin and PPAR-α genes in Alzheimer's disease: the Epistasis Project.

Abstract:

Altered glucose metabolism has been described in Alzheimer's disease (AD). We re-investigated the interaction of the insulin (INS) and the peroxisome proliferator-activated receptor alpha (PPARA) genes in AD risk in the Epistasis Project, including 1,757 AD cases and 6,294 controls. Allele frequencies of both SNPs (PPARA L162V, INS intron 0 A/T) differed between Northern Europeans and Northern Spanish. The PPARA 162LL genotype increased AD risk in Northern Europeans (p = 0.04), but not in Nor...

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Publication status:
Published

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Publisher copy:
10.1007/s00702-011-0732-4

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Journal:
Journal of neural transmission (Vienna, Austria : 1996) More from this journal
Volume:
119
Issue:
4
Pages:
473-479
Publication date:
2012-04-01
DOI:
EISSN:
1435-1463
ISSN:
0300-9564
Language:
English
Keywords:
Pubs id:
pubs:201410
UUID:
uuid:07f6a714-c8d8-4a68-b5e5-b6d2aee49319
Local pid:
pubs:201410
Source identifiers:
201410
Deposit date:
2012-12-19

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