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Different effects of isolation-rearing and neonatal MK-801 treatment on attentional modulations of prepulse inhibition of startle in rats

Abstract:

Rational
Prepulse inhibition (PPI) is suppression of the startle reflex by a weaker sensory stimulus (prepulse) preceding the startling stimulus. In people with schizophrenia, impairment of attentional modulation of PPI, but not impairment of baseline PPI, is correlated with symptom severity. In rats, both fear conditioning of prepulse and perceptually spatial separation between the conditioned prepulse and a noise masker enhance PPI (the paradigms of attentional modulation of PPI).

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1007/s00213-016-4351-5

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Institution:
University of Oxford
Department:
Oxford, MSD, Experimental Psychology
Publisher:
Springer Verlag Publisher's website
Journal:
Psychopharmacology Journal website
Publication date:
2016-07-01
DOI:
EISSN:
1432-2072
ISSN:
0033-3158
URN:
uuid:07f412b4-c2cb-4ab7-a97b-40c11b27f7dd
Source identifiers:
632954
Local pid:
pubs:632954

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