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New strategies for targeting the hypoxic tumour microenvironment in breast cancer.

Abstract:

Radiation and drug resistance remain major challenges and causes of mortality in the treatment of locally advanced, recurrent and metastatic breast cancer. Metabolic reprogramming is a recently recognised hallmark of cancer with the hypoxic acidic extracellular environment as a major driver of invasion and metastases. Nearly 40% of all breast cancers and 50% of locally advanced breast cancers are hypoxic and their altered metabolism is strongly linked to resistance to radiotherapy and systemi...

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Publication status:
Published

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Publisher copy:
10.1016/j.ctrv.2012.08.004

Authors


Langdon, SP More by this author
Harris, AL More by this author
Harrison, DJ More by this author
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Journal:
Cancer treatment reviews
Volume:
39
Issue:
2
Pages:
171-179
Publication date:
2013-04-05
DOI:
EISSN:
1532-1967
ISSN:
0305-7372
URN:
uuid:07f04c3b-a802-4d81-8a91-7d23514384b9
Source identifiers:
356717
Local pid:
pubs:356717

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