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Journal article

The toll-like receptor 4 Asp299Gly variant: no influence on LPS responsiveness or susceptibility to pulmonary tuberculosis in The Gambia.

Abstract:

SETTING: Tuberculosis (TB) remains a major cause of morbidity and mortality worldwide. Studies in a murine model of pulmonary TB have identified a role for Toll-like receptor 4 (TLR4) in the development of chronic lung infection with Mycobacterium tuberculosis. The Asp299Gly polymorphism in the human TLR4 gene is associated with in vivo hyporesponsiveness to lipopolysaccharide (LPS) in Caucasians. OBJECTIVE: To determine whether TLR4 Asp299Gly influences LPS responses or susceptibility to pul...

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Publication status:
Published

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Publisher copy:
10.1016/j.tube.2004.02.001

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Tropical Medicine
Role:
Author
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Journal:
Tuberculosis (Edinburgh, Scotland)
Volume:
84
Issue:
6
Pages:
347-352
Publication date:
2004-01-01
DOI:
EISSN:
1873-281X
ISSN:
1472-9792
URN:
uuid:07ee6d87-5e25-46d6-a019-4489b1a68932
Source identifiers:
32899
Local pid:
pubs:32899

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