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HIV viral set point and host immune control in individuals with HIV-specific CD8+ T-cell responses prior to HIV acquisition.

Abstract:

OBJECTIVE: Vaccine-induced CD8(+) T-cell responses in primates have been associated with a reduced simian immunodeficiency virus plasma viral load and enhanced T-cell responses, but cellular vaccines have shown limited success in human trials. We previously described HIV-specific T-cell responses in two groups of highly exposed, persistently seronegative Kenyan female sex workers, and a subset of these participants have subsequently acquired HIV. We examined the impact of pre-existing CD8(+) ...

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Publication status:
Published

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Journal:
AIDS (London, England) More from this journal
Volume:
24
Issue:
10
Pages:
1449-1454
Publication date:
2010-06-01
DOI:
EISSN:
1473-5571
ISSN:
0269-9370
Language:
English
Keywords:
Pubs id:
pubs:176643
UUID:
uuid:07dc967c-a971-4f3d-9da4-d60eabcd7a19
Local pid:
pubs:176643
Source identifiers:
176643
Deposit date:
2012-12-19

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