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Drug-resistant genotypes and multi-clonality in Plasmodium falciparum analysed by direct genome sequencing from peripheral blood of malaria patients

Abstract:

Naturally acquired blood-stage infections of the malaria parasite Plasmodium falciparum typically harbour multiple haploid clones. The apparent number of clones observed in any single infection depends on the diversity of the polymorphic markers used for the analysis, and the relative abundance of rare clones, which frequently fail to be detected among PCR products derived from numerically dominant clones. However, minority clones are of clinical interest as they may harbour genes conferring ...

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Authors


Robinson, T More by this author
Campino, SG More by this author
Assefa, SA More by this author
Polley, SD More by this author
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Journal:
PLoS ONE
Volume:
6
Issue:
8
Publication date:
2011
DOI:
EISSN:
1932-6203
URN:
uuid:07dc6f46-6829-435d-95ab-3d8b255aab79
Source identifiers:
179387
Local pid:
pubs:179387
Language:
English

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