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Journal article

HIV envelope gp120 alters T-cell receptor mobilization in the immunological synapse of uninfected CD4 T cells and augments the T cell activation

Abstract:

HIV is transmitted most efficiently from cell to cell and productive infection occurs mainly in activated CD4 T cells. It is postulated that HIV exploits immunological synapses formed between CD4 T cells and antigen-presenting cells to facilitate the targeting and infection of activated CD4 T cells. This study sought to evaluate how the presence of the HIV envelope (Env) in the CD4 T cell immunological synapse affects synapse formation and intracellular signaling to impact the downstream T ce...

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Publication status:
Published
Peer review status:
Peer reviewed

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Files:
Publisher copy:
10.1128/JVI.01532-16

Authors


More from this funder
Name:
Department of Veterans Affairs
Funding agency for:
Hioe, C
Grant:
AI102740
More from this funder
Name:
National Institute of Health
Funding agency for:
Dustin, M
Hioe, C
Grant:
AI043542
AI102740
Publisher:
American Society for Microbiology
Journal:
Journal of Virology More from this journal
Volume:
90
Issue:
23
Pages:
10513-10526
Publication date:
2016-09-14
Acceptance date:
2016-09-07
DOI:
EISSN:
1098-5514
ISSN:
0022-538X
Pmid:
27630246
Language:
English
Keywords:
Pubs id:
pubs:646066
UUID:
uuid:07d94a54-bfde-462f-9db7-4d1f776e6fac
Local pid:
pubs:646066
Source identifiers:
646066
Deposit date:
2016-11-03

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