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Targeting radiation-resistant hypoxic tumour cells through ATR inhibition.

Abstract:

BACKGROUND: Most solid tumours contain regions of sub-optimal oxygen concentration (hypoxia). Hypoxic cancer cells are more resistant to radiotherapy and represent the most aggressive fraction of a tumour. It is therefore essential that strategies continue to be developed to target hypoxic cancer cells. Inhibition of the DNA damage response (DDR) might be an effective way of sensitising hypoxic tumour cells to radiotherapy. METHODS: Here, we describe the cellular effects of pharmacological i...

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Publication status:
Published

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Publisher copy:
10.1038/bjc.2012.265

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Journal:
British journal of cancer More from this journal
Volume:
107
Issue:
2
Pages:
291-299
Publication date:
2012-07-01
DOI:
EISSN:
1532-1827
ISSN:
0007-0920

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