Journal article
Common variants near MC4R are associated with fat mass, weight and risk of obesity.
- Abstract:
-
To identify common variants influencing body mass index (BMI), we analyzed genome-wide association data from 16,876 individuals of European descent. After previously reported variants in FTO, the strongest association signal (rs17782313, P = 2.9 x 10(-6)) mapped 188 kb downstream of MC4R (melanocortin-4 receptor), mutations of which are the leading cause of monogenic severe childhood-onset obesity. We confirmed the BMI association in 60,352 adults (per-allele effect = 0.05 Z-score units; P = ...
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- Publication status:
- Published
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Bibliographic Details
- Journal:
- Nature genetics
- Volume:
- 40
- Issue:
- 6
- Pages:
- 768-775
- Publication date:
- 2008-06-01
- DOI:
- EISSN:
-
1546-1718
- ISSN:
-
1061-4036
- Source identifiers:
-
30601
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:30601
- UUID:
-
uuid:07d855ef-89fa-464a-92ae-2ae88d84d338
- Local pid:
- pubs:30601
- Deposit date:
- 2012-12-19
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- Copyright date:
- 2008
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