Journal article icon

Journal article

Common variants near MC4R are associated with fat mass, weight and risk of obesity.

Abstract:

To identify common variants influencing body mass index (BMI), we analyzed genome-wide association data from 16,876 individuals of European descent. After previously reported variants in FTO, the strongest association signal (rs17782313, P = 2.9 x 10(-6)) mapped 188 kb downstream of MC4R (melanocortin-4 receptor), mutations of which are the leading cause of monogenic severe childhood-onset obesity. We confirmed the BMI association in 60,352 adults (per-allele effect = 0.05 Z-score units; P = ...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1038/ng.140

Authors


More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, NDM, Human Genetics Wt Centre
Role:
Author
Expand authors...
Journal:
Nature genetics
Volume:
40
Issue:
6
Pages:
768-775
Publication date:
2008-06-05
DOI:
EISSN:
1546-1718
ISSN:
1061-4036
URN:
uuid:07d855ef-89fa-464a-92ae-2ae88d84d338
Source identifiers:
30601
Local pid:
pubs:30601

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP