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Journal article

Common variants near MC4R are associated with fat mass, weight and risk of obesity.

Abstract:

To identify common variants influencing body mass index (BMI), we analyzed genome-wide association data from 16,876 individuals of European descent. After previously reported variants in FTO, the strongest association signal (rs17782313, P = 2.9 x 10(-6)) mapped 188 kb downstream of MC4R (melanocortin-4 receptor), mutations of which are the leading cause of monogenic severe childhood-onset obesity. We confirmed the BMI association in 60,352 adults (per-allele effect = 0.05 Z-score units; P = ...

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Publication status:
Published

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Publisher copy:
10.1038/ng.140

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Human Genetics Wt Centre
Role:
Author
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Journal:
Nature genetics
Volume:
40
Issue:
6
Pages:
768-775
Publication date:
2008-06-01
DOI:
EISSN:
1546-1718
ISSN:
1061-4036
Source identifiers:
30601

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