Common variants near MC4R are associated with fat mass, weight and risk of obesity.

Loos, RJ; Lindgren, CM; Li, S; Wheeler, E; Zhao, JH; Prokopenko, I; Inouye, M; Freathy, RM; Attwood, AP; Beckmann, JS; Berndt, SI; Jacobs, KB; Chanock, SJ; Hayes, RB; Bergmann, S; Bennett, AJ; Bingham, SA; Bochud, M; Brown, M; Cauchi, S; Connell, JM; Cooper, C; Smith, GD; Day, I; Dina, C; De, S; Dermitzakis, ET; Doney, AS; Elliott, KS; Elliott, P; Evans, DM; Sadaf Farooqi, I; Froguel, P; Ghori, J; Groves, CJ; Gwilliam, R; Hadley, D; Hall, AS; Hattersley, AT; Hebebrand, J; Heid, IM; Lamina, C; Gieger, C; Illig, T; Meitinger, T; Wichmann, HE; Herrera, B; Hinney, A; Hunt, SE; Jarvelin, MR; Johnson, T; Jolley, JD; Karpe, F; Keniry, A; Khaw, KT; Luben, RN; Mangino, M; Marchini, J; McArdle, WL; McGinnis, R; Meyre, D; Munroe, PB; Morris, AD; Ness, AR; Neville, MJ; Nica, AC; Ong, KK; O'Rahilly, S; Owen, KR; Palmer, CN; Papadakis, K; Potter, S; Pouta, A; Qi, L; Randall, JC; Rayner, NW; Ring, SM; Sandhu, MS; Scherag, A; Sims, MA; Song, K; Soranzo, N; Speliotes, EK; Syddall, HE; Teichmann, SA; Timpson, NJ; Tobias, JH; Uda, M; Vogel, CI; Wallace, C; Waterworth, DM; Weedon, MN; Willer, CJ; Wraight; Yuan, X; Zeggini, E; Hirschhorn, JN; Strachan, DP; Ouwehand, WH; Caulfield, MJ; Samani, NJ; Frayling, TM; Vollenweider, P; Waeber, G; Mooser, V; Deloukas, P; McCarthy, MI; Wareham, NJ; Barroso, I; Jacobs, KB; Chanock, SJ; Hayes, RB; Lamina, C; Gieger, C; Illig, T; Meitinger, T; Wichmann, HE; Kraft, P; Hankinson, SE; Hunter, DJ; Hu, FB; Lyon, HN; Voight, BF; Ridderstrale, M; Groop, L; Scheet, P; Sanna, S; Abecasis, GR; Albai, G; Nagaraja, R; Schlessinger, D; Jackson, AU; Tuomilehto, J; Collins, FS; Boehnke, M; Mohlke, KL

Abstract:

To identify common variants influencing body mass index (BMI), we analyzed genome-wide association data from 16,876 individuals of European descent. After previously reported variants in FTO, the strongest association signal (rs17782313, P = 2.9 x 10(-6)) mapped 188 kb downstream of MC4R (melanocortin-4 receptor), mutations of which are the leading cause of monogenic severe childhood-onset obesity. We confirmed the BMI association in 60,352 adults (per-allele effect = 0.05 Z-score units; P = ...

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APA Style

Loos, R. J., Lindgren, C. M., Li, S., Wheeler, E., Zhao, J. H., Prokopenko, I., Inouye, M., Freathy, R. M., Attwood, A. P., Beckmann, J. S., Berndt, S. I., Jacobs, K. B., Chanock, S. J., Hayes, R. B., Bergmann, S., Bennett, A. J., Bingham, S. A., Bochud, M., Brown, M., … Mohlke, K. L. (2008). Common variants near MC4R are associated with fat mass, weight and risk of obesity. Nature Genetics, 40(6), 768–775.

MLA Style

Loos, R. J., et al. “Common Variants near MC4R Are Associated with Fat Mass, Weight and Risk of Obesity.” Nature Genetics, vol. 40, no. 6, Nature genetics, 2008, pp. 768–75.

Chicago Style

Loos, RJ, CM Lindgren, S Li, E Wheeler, JH Zhao, I Prokopenko, M Inouye, et al. 2008. “Common Variants near MC4R Are Associated with Fat Mass, Weight and Risk of Obesity.” Nature Genetics 40 (6): 768–75.
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