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Transmission of mitochondrial DNA diseases and ways to prevent them.

Abstract:

Recent reports of strong selection of mitochondrial DNA (mtDNA) during transmission in animal models of mtDNA disease, and of nuclear transfer in both animal models and humans, have important scientific implications. These are directly applicable to the genetic management of mtDNA disease. The risk that a mitochondrial disorder will be transmitted is difficult to estimate due to heteroplasmy-the existence of normal and mutant mtDNA in the same individual, tissue, or cell. In addition, the mtD...

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Publication status:
Published

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Institution:
University of Oxford
Division:
MSD
Department:
Women's and Reproductive Health
Role:
Author
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Journal:
PLoS genetics
Volume:
6
Issue:
8
Pages:
e1001066-e1001066
Publication date:
2010-08-01
DOI:
EISSN:
1553-7404
ISSN:
1553-7390
Source identifiers:
248264
Language:
English
Keywords:
Pubs id:
pubs:248264
UUID:
uuid:07d0ab8f-b4bf-4855-b747-fa518d8ee4c8
Local pid:
pubs:248264
Deposit date:
2013-11-16

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