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Putative re-entrant loop 1 of AE2 transmembrane domain has a major role in acute regulation of anion exchange by pH.

Abstract:

Normal pH sensitivity of the SLC4A2/AE2 anion exchanger requires transmembrane domain (TMD) amino acid (aa) residues not conserved in the homologous but relatively pH-insensitive SLC4A1/AE1 polypeptide. We tested the hypothesis that the nonconserved aa cluster 1075DKPK1078 within the first putative re-entrant loop (RL1) of AE2 TMD contributes to pH sensor function by studying anion exchange function of AE2 mutants in which these and other RL1 aa were systematically substituted with correspond...

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Publication status:
Published

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Publisher copy:
10.1074/jbc.m802051200

Authors


Stewart, AK More by this author
Kurschat, CE More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics, BHF Centre of Research Excellence
Journal:
The Journal of biological chemistry
Volume:
284
Issue:
10
Pages:
6126-6139
Publication date:
2009-03-05
DOI:
EISSN:
1083-351X
ISSN:
0021-9258
URN:
uuid:07cb31d6-5667-4896-bf86-f49868b79d0a
Source identifiers:
106452
Local pid:
pubs:106452

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