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Spreading dilatation to luminal perfusion of ATP and UTP in rat isolated small mesenteric arteries.

Abstract:

Levels of ATP achieved within the lumen of vessels suggest a key autacoid role. P2Y receptors on the endothelium may represent the target for ATP, leading to hyperpolarization and associated relaxation of vascular smooth muscle through the endothelium-dependent hyperpolarizing factor (EDHF) pathway. EDHF signals radially from the endothelium to cause dilatation, and appears mechanistically distinct from the axial spread of dilatation, which we showed occurs independently of a change in endoth...

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Publication status:
Published

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Institution:
University of Oxford
Division:
MSD
Department:
Pharmacology
Role:
Author
Journal:
Journal of physiology
Volume:
582
Issue:
Pt 1
Pages:
335-347
Publication date:
2007-07-01
DOI:
EISSN:
1469-7793
ISSN:
0022-3751
Source identifiers:
106144

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