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Small duct primary sclerosing cholangitis without inflammatory bowel disease is genetically different from large duct disease

Abstract:

Background and Aims: Small duct primary sclerosing cholangitis (PSC) is phenotypically a mild version of large duct PSC, but it is unknown whether these phenotypes share aetiology. We aimed to characterize their relationship by investigating genetic associations in the human leucocyte antigen (HLA) complex, which represent the strongest genetic risk factors in large duct PSC. Methods: Four classical HLA loci (HLA-A, HLA-B*, HLA-C and HLA-DRB1) were genotyped in 87 small duct PSC patients, 485...

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Publisher copy:
10.1111/liv.12492

Authors


Björnsson, E More by this author
Anmarkrud, JA More by this author
Mamari, SA More by this author
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Publisher:
Blackwell Publishing Ltd
Journal:
Liver International
Volume:
34
Issue:
10
Pages:
1488-1495
Publication date:
2014-11-01
DOI:
EISSN:
1478-3231
ISSN:
1478-3223
URN:
uuid:07c93418-bca9-46e1-a771-a61770bc2066
Source identifiers:
489617
Local pid:
pubs:489617

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