2001 Volvo Award Winner in Basic Science Studies: Effect of nutrient supply on the viability of cells from the nucleus pulposus of the intervertebral disc.

Journal article

STUDY DESIGN: Disc cell viability was analyzed in relation to nutrient supply and cellular demand in vitro in a diffusion chamber. OBJECTIVE: To determine relations among nutrient supply, nutrient concentrations. and cell viability. SUMMARY OF BACKGROUND DATA: Although a fall in nutrient supply has long been thought the cause of disc degeneration in vivo, little information exists about the effects of nutrient levels or supply on cell viability and metabolism. METHODS: Isolated bovine nucleus...

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Authors: Horner, H; Urban, J

• Publication status: Published
• Journal: Spine
• Volume: 26
• Issue: 23
• Pages: 2543-2549
• Publication date: 2001-12-01
• DOI: 10.1097/00007632-200112010-00006
• EISSN: 1528-1159
• ISSN: 0362-2436
• Language: English
• Keywords: Nutritional Physiological Phenomena; Diffusion Chambers, Culture; Cell Count; Male; Glycosaminoglycans; Animals; Cell Survival; Intervertebral Disk; Cattle; Oxygen; Dose-Response Relationship, Drug; Time Factors; Cells, Cultured