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Journal article

HES6 drives a critical AR transcriptional programme to induce castration‐resistant prostate cancer through activation of an E2F1‐mediated cell cycle network

Abstract:

Castrate‐resistant prostate cancer (CRPC) is poorly characterized and heterogeneous and while the androgen receptor (AR) is of singular importance, other factors such as c‐Myc and the E2F family also play a role in later stage disease. HES6 is a transcription co‐factor associated with stem cell characteristics in neural tissue. Here we show that HES6 is up‐regulated in aggressive human prostate cancer and drives castration‐resistant tumour growth in the absenc...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1002/emmm.201303581

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Institution:
University of Oxford
Division:
MSD
Department:
Surgical Sciences
Role:
Author
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Publisher:
EMBO Press Publisher's website
Journal:
EMBO Molecular Medicine Journal website
Volume:
6
Issue:
5
Pages:
651-661
Publication date:
2014-04-14
DOI:
EISSN:
1757-4684
ISSN:
1757-4676
Pmid:
24737870
Source identifiers:
467098
Keywords:
Pubs id:
pubs:467098
UUID:
uuid:07c3dda9-9ab6-4113-9d0d-8d4ceaf42a8a
Local pid:
pubs:467098
Deposit date:
2017-05-24

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