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Localization of double-stranded small interfering RNA to cytoplasmic processing bodies is Ago2 dependent and results in up-regulation of GW182 and Argonaute-2.

Abstract:

Processing bodies (P-bodies) are cytoplasmic foci implicated in the regulation of mRNA translation, storage, and degradation. Key effectors of microRNA (miRNA)-mediated RNA interference (RNAi), such as Argonaute-2 (Ago2), miRNAs, and their cognate mRNAs, are localized to these structures; however, the precise role that P-bodies and their component proteins play in small interfering RNA (siRNA)-mediated RNAi remains unclear. Here, we investigate the relationship between siRNA-mediated RNAi, RN...

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Publication status:
Published

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Publisher copy:
10.1091/mbc.e08-08-0796

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Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
Role:
Author
Journal:
Molecular biology of the cell
Volume:
20
Issue:
1
Pages:
521-529
Publication date:
2009-01-05
DOI:
EISSN:
1939-4586
ISSN:
1059-1524
URN:
uuid:07c09dd8-11e7-4a9f-985f-8fa1d603191b
Source identifiers:
101505
Local pid:
pubs:101505

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