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Living without creatine: Unchanged exercise capacity and response to chronic myocardial infarction in creatine-deficient mice

Abstract:

RATIONALE:: Creatine is thought to be involved in the spatial and temporal buffering of ATP in energetic organs such as heart and skeletal muscle. Creatine depletion affects force generation during maximal stimulation, while reduced levels of myocardial creatine are a hallmark of the failing heart, leading to the widely held view that creatine is important at high workloads and under conditions of pathological stress. OBJECTIVE:: We therefore hypothesised that the consequences of creatine-def...

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Authors


Lygate, CA More by this author
Aksentijevic, D More by this author
Ten Hove, M More by this author
Phillips, D More by this author
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Journal:
Circulation Research
Volume:
112
Issue:
6
Pages:
945-955
Publication date:
2013-03-15
DOI:
EISSN:
1524-4571
ISSN:
0009-7330
URN:
uuid:07bda1f7-74db-494f-86f8-aaba25928f17
Source identifiers:
394153
Local pid:
pubs:394153

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