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Piperacillin/tazobactam resistance in a clinical isolate of Escherichia coli due to IS26-mediated amplification of blaTEM-1B.

Abstract:

A phenotype of Escherichia coli and Klebsiella pneumoniae, resistant to piperacillin/tazobactam (TZP) but susceptible to carbapenems and 3rd generation cephalosporins, has emerged. The resistance mechanism associated with this phenotype has been identified as hyperproduction of the β-lactamase TEM. However, the mechanism of hyperproduction due to gene amplification is not well understood. Here, we report a mechanism of gene amplification due to a translocatable unit (TU) excising from a...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/s41467-020-18668-2

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Role:
Author
ORCID:
0000-0001-6668-9179
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Role:
Author
ORCID:
0000-0002-5609-1138
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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Role:
Author
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Department of Health More from this funder
Publisher:
Springer Nature Publisher's website
Journal:
Nature Communications Journal website
Volume:
11
Issue:
1
Article number:
4915
Publication date:
2020-10-01
Acceptance date:
2020-09-03
DOI:
EISSN:
2041-1723

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