Journal article
Piperacillin/tazobactam resistance in a clinical isolate of Escherichia coli due to IS26-mediated amplification of blaTEM-1B.
- Abstract:
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A phenotype of Escherichia coli and Klebsiella pneumoniae, resistant to piperacillin/tazobactam (TZP) but susceptible to carbapenems and 3rd generation cephalosporins, has emerged. The resistance mechanism associated with this phenotype has been identified as hyperproduction of the β-lactamase TEM. However, the mechanism of hyperproduction due to gene amplification is not well understood. Here, we report a mechanism of gene amplification due to a translocatable unit (TU) excising from a...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Version of record, 741.6KB)
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- Publisher copy:
- 10.1038/s41467-020-18668-2
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Authors
Funding
Department of Health
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Bibliographic Details
- Publisher:
- Springer Nature Publisher's website
- Journal:
- Nature Communications Journal website
- Volume:
- 11
- Issue:
- 1
- Article number:
- 4915
- Publication date:
- 2020-10-01
- Acceptance date:
- 2020-09-03
- DOI:
- EISSN:
-
2041-1723
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
1163548
- Local pid:
- pubs:1163548
- Deposit date:
- 2021-03-02
Terms of use
- Copyright holder:
- Hubbard et al.
- Copyright date:
- 2020
- Rights statement:
- ©2020 The Authors. Open Access. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
- Licence:
- CC Attribution (CC BY)
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