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DNA nanotweezers studied with a coarse-grained model of DNA.

Abstract:

We introduce a coarse-grained rigid nucleotide model of DNA that reproduces the basic thermodynamics of short strands, duplex hybridization, single-stranded stacking, and hairpin formation, and also captures the essential structural properties of DNA: the helical pitch, persistence length, and torsional stiffness of double-stranded molecules, as well as the comparative flexibility of unstacked single strands. We apply the model to calculate the detailed free-energy landscape of one full cycle...

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Institution:
University of Oxford
Division:
MPLS
Department:
Physics
Sub department:
Theoretical Physics
Role:
Author
Journal:
Physical Review Letters
Volume:
104
Issue:
17
Pages:
178101
Publication date:
2010-04-01
DOI:
EISSN:
1079-7114
ISSN:
0031-9007
Source identifiers:
54773
Language:
English
Keywords:
Pubs id:
pubs:54773
UUID:
uuid:07b9c01e-9ce1-4b14-9383-95564d81060b
Local pid:
pubs:54773
Deposit date:
2012-12-19

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