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Effects of intravenous immunoglobulin on muscle weakness and calcium-channel autoantibodies in the Lambert-Eaton myasthenic syndrome.

Abstract:

Intravenous immunoglobulin improves many antibody-mediated autoimmune disorders, but its mode of action is unknown. We investigated its effects on muscle strength and on the serum titer of the calcium-channel autoantibodies that are likely to be pathogenic in the Lambert-Eaton myasthenic syndrome (LEMS). In a randomized, double-blind, placebo-controlled crossover trial, serial indices of limb, respiratory, and bulbar muscle strength and the serum titer of calcium-channel antibodies in nine pa...

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Publisher copy:
10.1212/wnl.47.3.678

Authors


Motomura, M More by this author
Newsom-Davis, J More by this author
Misbah, SA More by this author
Chapel, HM More by this author
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Journal:
Neurology
Volume:
47
Issue:
3
Pages:
678-683
Publication date:
1996-09-05
DOI:
EISSN:
1526-632X
ISSN:
0028-3878
URN:
uuid:07b83591-76c1-4e40-bc1d-b562d7ce82ce
Source identifiers:
94168
Local pid:
pubs:94168

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