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Strong genetic evidence for a selective influence of GABAA receptors on a component of the bipolar disorder phenotype.

Abstract:

Despite compelling evidence for a major genetic contribution to risk of bipolar mood disorder, conclusive evidence implicating specific genes or pathophysiological systems has proved elusive. In part this is likely to be related to the unknown validity of current phenotype definitions and consequent aetiological heterogeneity of samples. In the recent Wellcome Trust Case Control Consortium genome-wide association analysis of bipolar disorder (1868 cases, 2938 controls) one of the most strongl...

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Publication status:
Published

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Publisher copy:
10.1038/mp.2008.66

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Journal:
Molecular psychiatry
Volume:
15
Issue:
2
Pages:
146-153
Publication date:
2010-02-01
DOI:
EISSN:
1476-5578
ISSN:
1359-4184
Source identifiers:
88504

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