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Journal article

CD8+ T-cell responses to different HIV proteins have discordant associations with viral load.

Abstract:

Selection of T-cell vaccine antigens for chronic persistent viral infections has been largely empirical. To define the relationship, at the population level, between the specificity of the cellular immune response and viral control for a relevant human pathogen, we performed a comprehensive analysis of the 160 dominant CD8(+) T-cell responses in 578 untreated HIV-infected individuals from KwaZulu-Natal, South Africa. Of the HIV proteins targeted, only Gag-specific responses were associated wi...

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Publication status:
Published

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Publisher copy:
10.1038/nm1520

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Journal:
Nature medicine
Volume:
13
Issue:
1
Pages:
46-53
Publication date:
2007-01-05
DOI:
EISSN:
1546-170X
ISSN:
1078-8956
URN:
uuid:07b58c46-f282-4f24-8e4a-5c2e460fdb96
Source identifiers:
27200
Local pid:
pubs:27200

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