- Abstract:
-
Regulation of integrin affinity (activation) is essential for metazoan development and for many pathological processes. Binding of the talin phosphotyrosine-binding (PTB) domain to integrin beta subunit cytoplasmic domains (tails) causes activation, whereas numerous other PTB-domain-containing proteins bind integrins without activating them. Here we define the structure of a complex between talin and the membrane-proximal integrin beta3 cytoplasmic domain and identify specific contacts betwee...
Expand abstract - Publisher copy:
- 10.1016/j.cell.2006.10.048
-
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- Journal:
- Cell
- Volume:
- 128
- Issue:
- 1
- Pages:
- 171-182
- Publication date:
- 2007-01-05
- DOI:
- EISSN:
-
1097-4172
- ISSN:
-
0092-8674
- URN:
-
uuid:07b4ec11-8df5-4ab4-b553-7054cd4464d6
- Source identifiers:
-
246502
- Local pid:
- pubs:246502
- Language:
- English
- Keywords:
- Copyright date:
- 2007
Journal article
Structural basis of integrin activation by talin.
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