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Structural basis of integrin activation by talin.

Abstract:

Regulation of integrin affinity (activation) is essential for metazoan development and for many pathological processes. Binding of the talin phosphotyrosine-binding (PTB) domain to integrin beta subunit cytoplasmic domains (tails) causes activation, whereas numerous other PTB-domain-containing proteins bind integrins without activating them. Here we define the structure of a complex between talin and the membrane-proximal integrin beta3 cytoplasmic domain and identify specific contacts betwee...

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Publisher copy:
10.1016/j.cell.2006.10.048

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Journal:
Cell More from this journal
Volume:
128
Issue:
1
Pages:
171-182
Publication date:
2007-01-01
DOI:
EISSN:
1097-4172
ISSN:
0092-8674

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