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In vitro model for the assessment of luminal factors on rectal mucosa.

Abstract:

An organ culture method for the maintenance of rectal biopsies over a period of 24 hours is described. Good preservation of histological architecture and continued crypt cell proliferation were shown over the culture period. The colonic enzyme alkaline phosphatase was found to rise over the period of culture. This rise was dependent upon continued protein synthesis by the cell. Changes in alkaline phosphatase activity during culture in biopsies from patients with ulcerative colitis and Crohn'...

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Publication status:
Published

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Publisher copy:
10.1136/gut.24.9.812
Journal:
Gut More from this journal
Volume:
24
Issue:
9
Pages:
812-817
Publication date:
1983-09-01
DOI:
EISSN:
1468-3288
ISSN:
0017-5749
Language:
English
Keywords:
Pubs id:
pubs:135551
UUID:
uuid:07b1de41-5b4f-4711-8083-7c5400cde303
Local pid:
pubs:135551
Source identifiers:
135551
Deposit date:
2012-12-19

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