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Effect of a 2-week interruption in methotrexate treatment versus continued treatment on COVID-19 booster vaccine immunity in adults with inflammatory conditions (VROOM study): a randomised, open label, superiority trial

Abstract:
Background
Immunosuppressive treatments inhibit vaccine-induced immunity against SARS-CoV-2. We evaluated whether a 2-week interruption of methotrexate treatment immediately after the COVID-19 vaccine booster improved antibody responses against the S1 receptor-binding domain (S1-RBD) of the SARS-CoV-2 spike protein compared with uninterrupted treatment in patients with immune-mediated inflammatory diseases.
Methods
We did an open-label, prospecti... Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

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Files:
Publisher copy:
10.1016/s2213-2600(22)00186-2

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Sub department:
Botnar Research Centre
Role:
Author
ORCID:
0000-0002-4756-663X

Contributors

Publisher:
Elsevier Publisher's website
Journal:
The Lancet. Respiratory medicine Journal website
Volume:
10
Issue:
9
Pages:
840-850
Publication date:
2022-06-27
Acceptance date:
2022-05-12
DOI:
EISSN:
2213-2619
ISSN:
2213-2600
Pmid:
35772416
Language:
English
Keywords:
Pubs id:
1266433
Local pid:
pubs:1266433
Deposit date:
2022-07-04

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