Integron-mediated antibiotic multiresistance in Acinetobacter baumannii clinical isolates from Spain.

Journal article

OBJECTIVE: To determine whether non-epidemiologically related, antibiotic-resistant isolates of Acinetobacter baumannii from different geographical origins possess common type 1 integrons. METHODS: The epidemiologic relationships between seven A. baumannii strains recovered from different Spanish hospitals were established by pulsed-field gel electrophoresis, the presence of integrons being determined by PCR and DNA sequencing. RESULTS: Integron analysis showed the presence of four different integrons, containing six different known genes (aacC1, aacA4, aadA1, aadB, oxa21 and oxa37) plus an ORF. It was found that the same integron was present in different unrelated strains and that related strains could have different integrons. CONCLUSION: These results show the potential risk of integron dissemination among different strains of A. baumannii.

Authors: Ruiz, J; Navia, M; Casals, C; Sierra, J; Jiménez De Anta, M

• Publication status: Published
• Journal: Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases
• Volume: 9
• Issue: 9
• Pages: 907-911
• Publication date: 2003-09-01
• DOI: 10.1046/j.1469-0691.2003.00561.x
• EISSN: 1469-0691
• ISSN: 1198-743X
• Language: English
• Keywords: Phylogeny; Sequence Analysis, DNA; DNA, Bacterial; Acinetobacter Infections; Humans; Microbial Sensitivity Tests; Integrons; Spain; Acinetobacter baumannii; Drug Resistance, Multiple, Bacterial; Polymerase Chain Reaction; Electrophoresis, Gel, Pulsed-Field