Parafibromin--functional insights.

Journal article

Parafibromin is a predominantly nuclear protein with a tumour suppressor role in the development of hereditary and nonhereditary parathyroid carcinomas, and the hyperparathyroidism-jaw tumour syndrome, which is associated with renal and uterine tumours. Parafibromin is a component of the highly conserved PAF1 complex, which regulates transcriptional events and histone modifications. The parafibromin/PAF1 complex regulates genes involved in cell growth and survival, and via these, parafibromin plays a pivotal role in embryonic development and survival of adults.

Authors: Newey, P; Bowl, MR; Thakker, R

• Publication status: Published
• Journal: Journal of internal medicine
• Volume: 266
• Issue: 1
• Pages: 84-98
• Publication date: 2009-07-01
• DOI: 10.1111/j.1365-2796.2009.02107.x
• EISSN: 1365-2796
• ISSN: 0954-6820
• Language: English
• Keywords: Amino Acid Sequence; Humans; Jaw Neoplasms; Molecular Sequence Data; Animals; Neoplasm Proteins; Genetic Predisposition to Disease; Hyperparathyroidism; Neoplastic Syndromes, Hereditary; Tumor Suppressor Proteins; Parathyroid Neoplasms