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HIF-1 and HIF-2: working alone or together in hypoxia?

Abstract:

Erythropoietin (EPO) is the hormonal regulator of red cell production and provided the paradigm for oxygen-regulated gene expression that led to the discovery of hypoxia-inducible factor (HIF). In this issue of the JCI, Rankin and colleagues show, using targeted gene inactivation, that induction of Epo expression in murine liver is dependent on the integrity of HIF-2alpha, and not HIF-1alpha (see the related article beginning on page 1068). These results demonstrate distinct functions for dif...

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Publication status:
Published

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Publisher copy:
10.1172/jci31750

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
CCMP
Role:
Author
Journal:
Journal of clinical investigation
Volume:
117
Issue:
4
Pages:
862-865
Publication date:
2007-04-01
DOI:
EISSN:
1558-8238
ISSN:
0021-9738
Source identifiers:
18299
Language:
English
Keywords:
Pubs id:
pubs:18299
UUID:
uuid:079c14ae-dbba-4c89-a445-d0663b3a373e
Local pid:
pubs:18299
Deposit date:
2012-12-19

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