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T cells get by with a little help from their friends

Abstract:

In animal models, lymphocytic choriomeningitis virus (LCMV) may be controlled after acute infection or may establish various levels of persistence. Cytotoxic responses mediated by CD8+ T cells are responsible for both initial control of LCMV and for immunopathology. As discussed in this article, there is emerging evidence that the levels of antigen to which the immune system is exposed over time are important in controlling CD8+ T cell activation, memory responses and exhaustion, and that the...

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Publication status:
Published

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Publisher copy:
10.1002/eji.200324844

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Experimental Medicine Division, Biomedical Research Centre
Journal:
EUROPEAN JOURNAL OF IMMUNOLOGY
Volume:
34
Issue:
2
Pages:
313-316
Publication date:
2004-02-05
DOI:
ISSN:
0014-2980
URN:
uuid:07992dcd-90d5-4e87-8fe5-8dfb3641e0f5
Source identifiers:
9524
Local pid:
pubs:9524
Language:
English
Keywords:

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