Journal article icon

Journal article

Dominant and recessive inheritance of morbid obesity associated with melanocortin 4 receptor deficiency.

Abstract:

Over 20 severely obese subjects in 11 independent kindreds have been reported to have pathogenic heterozygous mutations in the gene encoding the melanocortin 4 receptor (MC4R), making this the most common known monogenic cause of human obesity. To date, the detailed clinical phenotype of this dominantly inherited disorder has not been defined, and no homozygous subjects have been described. We determined the nucleotide sequence of the entire coding region of the MC4R gene in 243 subjects with...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1172/jci9397

Authors


Expand authors...
Journal:
The Journal of clinical investigation
Volume:
106
Issue:
2
Pages:
271-279
Publication date:
2000-07-05
DOI:
EISSN:
1558-8238
ISSN:
0021-9738
URN:
uuid:07966ef2-bc7e-4cd1-bb7d-cb1f1c94873e
Source identifiers:
429907
Local pid:
pubs:429907

Terms of use


Metrics


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP