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Functional studies of BCL11A: characterization of the conserved BCL11A-XL splice variant and its interaction with BCL6 in nuclear paraspeckles of germinal center B cells.

Abstract:

BACKGROUND: Chromosomal aberrations of BCL11A at 2p16.1 have been reported in a variety of B-cell malignancies and its deficiency in mice leads to a profound block in B-cell development. RESULTS: Alternative pre-mRNA splicing of BCL11A produces multiple isoforms sharing a common N-terminus. The most abundant isoform we have identified in human lymphoid samples is BCL11A-XL, the longest transcript produced at this locus, and here we report the conservation of this major isoform and its functio...

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Publication status:
Published

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Publisher copy:
10.1186/1476-4598-5-18

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Journal:
Molecular cancer More from this journal
Volume:
5
Pages:
18
Publication date:
2006-01-01
DOI:
EISSN:
1476-4598
ISSN:
1476-4598

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