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The use of sonicated lipid vesicles for mass spectrometry of membrane protein complexes

Abstract:

Recent applications of mass spectrometry (MS) to study membrane protein complexes are yielding valuable insights into the binding of lipids and their structural and functional roles. To date, most native MS experiments with membrane proteins are based on detergent solubilization. Many insights into the structure and function of membrane proteins have been obtained using detergents; however, these can promote local lipid rearrangement and can cause fluctuations in the oligomeric state of prote...

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Publication status:
Published
Peer review status:
Peer reviewed

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Role:
Author
ORCID:
0000-0002-0751-0092
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Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Physical & Theoretical Chem
Role:
Author
ORCID:
0000-0003-4346-182X
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Name:
Wellcome Trust
Grant:
202231/Z/16/Z
Publisher:
Nature Research
Journal:
Nature Protocols More from this journal
Volume:
15
Pages:
1690-1706
Publication date:
2020-04-01
Acceptance date:
2020-01-23
DOI:
EISSN:
1750-2799
ISSN:
1754-2189
Pmid:
32238951
Language:
English
Keywords:
Pubs id:
1098606
Local pid:
pubs:1098606
Deposit date:
2020-04-20

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