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Structure and functional characterization of the atypical human kinase haspin.

Abstract:

The protein kinase haspin/Gsg2 plays an important role in mitosis, where it specifically phosphorylates Thr-3 in histone H3 (H3T3). Its protein sequence is only weakly homologous to other protein kinases and lacks the highly conserved motifs normally required for kinase activity. Here we report structures of human haspin in complex with ATP and the inhibitor iodotubercidin. These structures reveal a constitutively active kinase conformation, stabilized by haspin-specific inserts. Haspin also ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1073/pnas.0901989106

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Publisher:
National Academy of Sciences Publisher's website
Journal:
Proceedings of the National Academy of Sciences of the United States of America Journal website
Volume:
106
Issue:
48
Pages:
20198-203
Publication date:
2009-01-01
DOI:
ISSN:
1091-6490
Language:
English
Subjects:
UUID:
uuid:0791b8d3-9046-4704-afa6-ab92558a32b3
Local pid:
SGC:19918057
Deposit date:
2011-08-18

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