Journal article
Structure and functional characterization of the atypical human kinase haspin.
- Abstract:
-
The protein kinase haspin/Gsg2 plays an important role in mitosis, where it specifically phosphorylates Thr-3 in histone H3 (H3T3). Its protein sequence is only weakly homologous to other protein kinases and lacks the highly conserved motifs normally required for kinase activity. Here we report structures of human haspin in complex with ATP and the inhibitor iodotubercidin. These structures reveal a constitutively active kinase conformation, stabilized by haspin-specific inserts. Haspin also ...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Publisher copy:
- 10.1073/pnas.0901989106
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Authors
Bibliographic Details
- Publisher:
- National Academy of Sciences Publisher's website
- Journal:
- Proceedings of the National Academy of Sciences of the United States of America Journal website
- Volume:
- 106
- Issue:
- 48
- Pages:
- 20198-203
- Publication date:
- 2009-01-01
- DOI:
- ISSN:
-
1091-6490
Item Description
- Language:
- English
- Subjects:
- UUID:
-
uuid:0791b8d3-9046-4704-afa6-ab92558a32b3
- Local pid:
- SGC:19918057
- Deposit date:
- 2011-08-18
Related Items
Terms of use
- Copyright holder:
- US Department of Health and Human Services. National Institutes of Health. National Cancer Institute. Canadian Institutes of Health Research. Wellcome Trust. Eswaran et al
- Copyright date:
- 2009
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