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Potential intermediates for incorporation of polyhydroxylated prolines into combinatorial libraries

Abstract:

Bicyclic 2 and monocyclic 6 2-amino-1,4-lactones provide divergent intermediates for subsequent incorporation of polyhydroxylated prolines into combinatorial amide libraries. The X-ray crystal structure of an azidolactone, combined with molecular modelling, rationalises the very different behaviour of two azidolactones which are epimeric at a remote side- chain carbon. The conversion of 2 and 6 into DGDP 4 secures the structural claims in the paper. The enantiomers of 2 and 6 may provide acce...

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Publication status:
Published

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Journal:
TETRAHEDRON LETTERS
Volume:
39
Issue:
33
Pages:
6091-6094
Publication date:
1998-08-13
DOI:
ISSN:
0040-4039
URN:
uuid:078f0384-7135-41ef-a76a-0ed75d54128a
Source identifiers:
36670
Local pid:
pubs:36670
Language:
English

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