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Delay differential equations and the dose-time dependence of early radiotherapy reactions.

Abstract:

The dose-time dependence of early radiotherapy reactions impacts on the design of accelerated fractionation schedules--oral mucositis, for example, can be dose limiting for short treatments designed to avoid tumor repopulation. In this paper a framework for modeling early reaction dose-time dependence is developed. Variation of stem cell number with time after the start of a radiation schedule is modeled using a first-order delay differential equation (DDE), motivated by experimental observat...

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Publication status:
Published

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Publisher copy:
10.1118/1.2241995

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Oncology
Role:
Author
Journal:
Medical physics More from this journal
Volume:
33
Issue:
9
Pages:
3526-3540
Publication date:
2006-09-01
DOI:
ISSN:
0094-2405
Language:
English
Keywords:
Pubs id:
pubs:228630
UUID:
uuid:078787bd-6e4e-4e7d-8136-c8e8340ee1ca
Local pid:
pubs:228630
Source identifiers:
228630
Deposit date:
2012-12-19

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