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NAADP induces pH changes in the lumen of acidic Ca2+ stores.

Abstract:

NAADP (nicotinic acid-adenine dinucleotide phosphate)-induced Ca2+ release has been proposed to occur selectively from acidic stores in several cell types, including sea urchin eggs. Using fluorescence measurements, we have investigated whether NAADP-induced Ca2+ release alters the pH(L) (luminal pH) within these acidic stores in egg homogenates and observed their prompt, concentration-dependent alkalinization by NAADP (but not beta-NAD+ or NADP). Like Ca2+ release, the pH(L) change was desen...

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Publication status:
Published

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Publisher copy:
10.1042/bj20060759

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Institution:
University of Oxford
Division:
MSD
Department:
Pharmacology
Role:
Author
Journal:
Biochemical journal More from this journal
Volume:
402
Issue:
2
Pages:
301-310
Publication date:
2007-03-01
DOI:
EISSN:
1470-8728
ISSN:
0264-6021
Language:
English
Keywords:
Pubs id:
pubs:106519
UUID:
uuid:07875f46-351f-4806-90bc-5bb2d2c9f7a3
Local pid:
pubs:106519
Source identifiers:
106519
Deposit date:
2012-12-19

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