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Journal article

The C-terminus of Apc does not influence intestinal adenoma development or progression

Abstract:

Adenomatous polyposis coli (APC) mutations are found in most colorectal tumours. These mutations are almost always protein-truncating, deleting both central domains that regulate Wnt signalling and C-terminal domains that interact with the cytoskeleton. The importance of Wnt dysregulation for colorectal tumourigenesis is well characterized. It is, however, unclear whether loss of C-terminal functions contributes to tumourigenesis, although this protein region has been implicated in cellular p...

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Publisher copy:
10.1002/path.2972

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Journal:
Journal of Pathology
Volume:
226
Issue:
1
Pages:
73-83
Publication date:
2012-01-01
DOI:
EISSN:
1096-9896
ISSN:
0022-3417
Source identifiers:
221564
Language:
English
Keywords:
Pubs id:
pubs:221564
UUID:
uuid:0785daad-dd7b-4ee4-80f4-a935931a29a8
Local pid:
pubs:221564
Deposit date:
2012-12-19

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