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Novel inhibitors of a Grb2 SH3C domain interaction identified by a virtual screen

Abstract:: The adaptor protein Grb2 links cell-surface receptors, such as Her2, to the multisite docking proteins Gab1 and 2, leading to cell growth and proliferation in breast and other cancers. Gab2 interacts with the C-terminal SH3 domain (SH3C) of Grb2 through atypical RxxK motifs within polyproline II or 3 10 helices. A virtual screen was conducted for putative binders of the Grb2 SH3C domain. Of the top hits, 34 were validated experimentally by surface plasmon resonance spectroscopy and isothermal...
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APA Style

Simister, P., Luccarelli, J., Thompson, S., Appella, D., Feller, S., & Hamilton, A. (2013). Novel inhibitors of a Grb2 SH3C domain interaction identified by a virtual screen. Bioorganic and Medicinal Chemistry, 21(14), 4027–4033.

MLA Style

Simister, P., et al. “Novel Inhibitors of a Grb2 SH3C Domain Interaction Identified by a Virtual Screen.” Bioorganic and Medicinal Chemistry, vol. 21, no. 14, 2013, pp. 4027–33.

Chicago Style

Simister, P, J Luccarelli, S Thompson, D Appella, S Feller, and A Hamilton. 2013. “Novel Inhibitors of a Grb2 SH3C Domain Interaction Identified by a Virtual Screen.” Bioorganic and Medicinal Chemistry 21 (14): 4027–33.
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Publisher copy:: 10.1016/j.bmc.2012.10.023

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+ Luccarelli, J More by this author

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+ Thompson, S More by this author

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+ Appella, D More by this author

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+ Feller, S More by this author

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Bibliographic Details

Journal:: Bioorganic and Medicinal Chemistry
Volume:: 21
Issue:: 14
Pages:: 4027-4033
Publication date:: 2013-07-15
DOI:: 10.1016/j.bmc.2012.10.023
EISSN:: 1464-3391
ISSN:: 0968-0896

Item Description

Language:: English
Keywords:: Virtual screening

Inhibitors

Grb2

Gab2

Protein-protein interaction

SH3 Domain
Pubs id:: pubs:409837
UUID:: uuid:07839a53-1160-46b8-9aa0-ca3a2e20f528
Local pid:: pubs:409837
Source identifiers:: 409837
Deposit date:: 2013-11-16

Terms of use

Copyright date:: 2013

Licence:: Terms and Conditions of Use for Oxford University Research Archive

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