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Journal article

Re-establishing immunological self-tolerance in autoimmune disease.

Abstract:

Recent progress has revealed the molecular basis of how self-reactive T cells are normally generated in the immune system and differentiate into autoimmune effector T cells and how they are controlled by central and peripheral mechanisms of self-tolerance. There is also evidence that target tissues and cells in autoimmune disease have different sensitivities to immune mediators. Here we describe how these basic findings can be clinically translated to re-establish self-tolerance in individual...

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Publication status:
Published

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Publisher copy:
10.1038/nm.2622
Journal:
Nature medicine More from this journal
Volume:
18
Issue:
1
Pages:
54-58
Publication date:
2012-01-01
DOI:
EISSN:
1546-170X
ISSN:
1078-8956
Language:
English
Keywords:
Pubs id:
pubs:254348
UUID:
uuid:07834b9b-ee25-4a73-afe9-77646efdb394
Local pid:
pubs:254348
Source identifiers:
254348
Deposit date:
2012-12-19

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