Re-establishing immunological self-tolerance in autoimmune disease.

Journal article

Recent progress has revealed the molecular basis of how self-reactive T cells are normally generated in the immune system and differentiate into autoimmune effector T cells and how they are controlled by central and peripheral mechanisms of self-tolerance. There is also evidence that target tissues and cells in autoimmune disease have different sensitivities to immune mediators. Here we describe how these basic findings can be clinically translated to re-establish self-tolerance in individual...

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Authors: Sakaguchi, S; Powrie, F; Ransohoff, R

• Publication status: Published
• Journal: Nature medicine
• Volume: 18
• Issue: 1
• Pages: 54-58
• Publication date: 2012-01-01
• DOI: 10.1038/nm.2622
• EISSN: 1546-170X
• ISSN: 1078-8956
• Language: English
• Keywords: Humans; Animals; Cell Differentiation; Autoimmune Diseases; Autoantigens; Translational Medical Research; Mice; T-Lymphocytes, Regulatory; Genome-Wide Association Study; Forkhead Transcription Factors; Self Tolerance