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Journal article

Characterization of transcriptional networks in blood stem and progenitor cells using high-throughput single-cell gene expression analysis.

Abstract:

Cellular decision-making is mediated by a complex interplay of external stimuli with the intracellular environment, in particular transcription factor regulatory networks. Here we have determined the expression of a network of 18 key haematopoietic transcription factors in 597 single primary blood stem and progenitor cells isolated from mouse bone marrow. We demonstrate that different stem/progenitor populations are characterized by distinctive transcription factor expression states, and thro...

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Publication status:
Published

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Publisher copy:
10.1038/ncb2709

Authors


Moignard, V More by this author
Macaulay, IC More by this author
Buettner, F More by this author
Schütte, J More by this author
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Journal:
Nature cell biology
Volume:
15
Issue:
4
Pages:
363-372
Publication date:
2013-04-05
DOI:
EISSN:
1476-4679
ISSN:
1465-7392
URN:
uuid:0779d87d-b124-43b5-ae20-1ae97a00990f
Source identifiers:
390972
Local pid:
pubs:390972

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