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Journal article

Melanopsin regulates both sleep-promoting and arousal-promoting responses to light

Abstract:

Light plays a critical role in the regulation of numerous aspects of physiology and behaviour, including the entrainment of circadian rhythms and the regulation of sleep. These responses involve melanopsin (OPN4)-expressing photosensitive retinal ganglion cells (pRGCs) in addition to rods and cones. Nocturnal light exposure in rodents has been shown to result in rapid sleep induction, in which melanopsin plays a key role. However, studies have also shown that light exposure can result in elev...

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Publication status:
Published
Peer review status:
Peer reviewed

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More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Clinical Neurosciences
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Clinical Neurosciences
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Clinical Neurosciences
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Clinical Neurosciences
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Clinical Neurosciences
Role:
Author
More from this funder
Name:
Wellcome Trust
Funding agency for:
Peirson, S
Foster, R
Grant:
098461/Z/12/Z
098461/Z/12/Z
098461/Z/12/Z
More from this funder
Name:
Biotechnology and Biological Sciences Research Council
Funding agency for:
Peirson, S
Foster, R
Grant:
098461/Z/12/Z
BB/I021086/1
098461/Z/12/Z
Publisher:
Public Library of Science
Journal:
PLoS Biology More from this journal
Volume:
14
Issue:
6
Article number:
e1002482
Publication date:
2016-01-01
Acceptance date:
2016-05-13
DOI:
ISSN:
1545-7885
Pubs id:
pubs:627038
UUID:
uuid:077767d9-049d-441b-9195-51d6a0a1ee72
Local pid:
pubs:627038
Source identifiers:
627038
Deposit date:
2016-06-09

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