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Epigenetic markers in inflammation-related genes associated with mood disorder: a cross-sectional and longitudinal study in high-risk offspring of bipolar parents

Abstract:

Bipolar disorder is highly heritable and typically onsets in late adolescence or early adulthood. Evidence suggests that immune activation may be a mediating pathway between genetic predisposition and onset of mood disorders. Building on a prior study of mRNA and protein levels in high-risk offspring published in this Journal, we conducted a preliminary examination of methylation profiles in candidate immune genes from a subsample of well-characterized emergent adult (mean 20 years) offspring...

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Publication status:
Published
Peer review status:
Peer reviewed

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Institution:
University of Oxford
Division:
MSD
Department:
Psychiatry
Oxford college:
All Souls College
Role:
Author
ORCID:
0000-0002-5895-075X
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Name:
Canadian Institutes of Health Research
Grant:
152976
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Name:
Hotchkiss Brain Institute, Calgary, Alberta (CA)
Grant:
Pilot Research Fund 2014
Publisher:
Springer Nature
Journal:
International Journal of Bipolar Disorders More from this journal
Volume:
7
Issue:
1
Article number:
17
Publication date:
2019-08-06
Acceptance date:
2019-07-01
DOI:
ISSN:
2194-7511
Pmid:
31385059
Language:
English
Keywords:
Pubs id:
pubs:1041740
UUID:
uuid:07713fff-b854-4a7b-93ed-b3b1cd9f84b0
Local pid:
pubs:1041740
Source identifiers:
1041740
Deposit date:
2019-10-08

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