Glycosphingolipids (GSLs) are essential constituents of cell membranes and lipid rafts and can modulate signal transduction events. The contribution of GSLs in osteoclast (OC) activation and osteolytic bone diseases in malignancies such as the plasma cell dyscrasia multiple myeloma (MM) is not known. Here, we tested the hypothesis that pathological activation of OCs in MM requires de novo GSL synthesis and is further enhanced by myeloma cell-derived GSLs. Glucosylceramide synthase (GCS) inhib...Expand abstract
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- American Society for Clinical Investigation Publisher's website
- Journal of Clinical Investigation Journal website
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- American Society for Clinical Investigation
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- Copyright © 2015, The American Society for Clinical Investigation.
Glycosphingolipid synthesis inhibition limits osteoclast activation and myeloma bone disease.
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