Journal article
Glycosphingolipid synthesis inhibition limits osteoclast activation and myeloma bone disease.
- Abstract:
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Glycosphingolipids (GSLs) are essential constituents of cell membranes and lipid rafts and can modulate signal transduction events. The contribution of GSLs in osteoclast (OC) activation and osteolytic bone diseases in malignancies such as the plasma cell dyscrasia multiple myeloma (MM) is not known. Here, we tested the hypothesis that pathological activation of OCs in MM requires de novo GSL synthesis and is further enhanced by myeloma cell-derived GSLs. Glucosylceramide synthase (GCS) inhib...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Version of record, pdf, 5.6MB)
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- Publisher copy:
- 10.1172/jci59987
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Authors
Funding
Multiple Myeloma Research Foundation
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Bibliographic Details
- Publisher:
- American Society for Clinical Investigation Publisher's website
- Journal:
- Journal of Clinical Investigation Journal website
- Volume:
- 125
- Issue:
- 6
- Pages:
- 2279-2292
- Publication date:
- 2015-01-01
- Acceptance date:
- 2015-03-19
- DOI:
- EISSN:
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1558-8238
- ISSN:
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0021-9738
- Source identifiers:
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521692
Item Description
- Language:
- English
- Keywords:
- Pubs id:
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pubs:521692
- UUID:
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uuid:076b11d1-0ae4-4cd2-b125-78857a0359b7
- Local pid:
- pubs:521692
- Deposit date:
- 2016-03-09
Terms of use
- Copyright holder:
- American Society for Clinical Investigation
- Copyright date:
- 2015
- Notes:
- Copyright © 2015, The American Society for Clinical Investigation.
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