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Glycosphingolipid synthesis inhibition limits osteoclast activation and myeloma bone disease.

Abstract:

Glycosphingolipids (GSLs) are essential constituents of cell membranes and lipid rafts and can modulate signal transduction events. The contribution of GSLs in osteoclast (OC) activation and osteolytic bone diseases in malignancies such as the plasma cell dyscrasia multiple myeloma (MM) is not known. Here, we tested the hypothesis that pathological activation of OCs in MM requires de novo GSL synthesis and is further enhanced by myeloma cell-derived GSLs. Glucosylceramide synthase (GCS) inhib...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1172/jci59987

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS, KIR
Antonopoulos, A More by this author
Butters, TD More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS, KIR
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Publisher:
American Society for Clinical Investigation Publisher's website
Journal:
Journal of Clinical Investigation Journal website
Volume:
125
Issue:
6
Pages:
2279-2292
Publication date:
2015
DOI:
EISSN:
1558-8238
ISSN:
0021-9738
URN:
uuid:076b11d1-0ae4-4cd2-b125-78857a0359b7
Source identifiers:
521692
Local pid:
pubs:521692

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