Glycosphingolipid synthesis inhibition limits osteoclast activation and myeloma bone disease.
Glycosphingolipids (GSLs) are essential constituents of cell membranes and lipid rafts and can modulate signal transduction events. The contribution of GSLs in osteoclast (OC) activation and osteolytic bone diseases in malignancies such as the plasma cell dyscrasia multiple myeloma (MM) is not known. Here, we tested the hypothesis that pathological activation of OCs in MM requires de novo GSL synthesis and is further enhanced by myeloma cell-derived GSLs. Glucosylceramide synthase (GCS) inhib...Expand abstract
- Publication status:
- Peer review status:
- Peer reviewed
- Pubs id:
- Local pid:
- Deposit date:
- Copyright holder:
- American Society for Clinical Investigation
- Copyright date:
- Copyright © 2015, The American Society for Clinical Investigation.
If you are the owner of this record, you can report an update to it here: Report update to this record